Local inflammatory response to gastroesophageal reflux: Association of gene expression of inflammatory cytokines with esophageal multichannel intraluminal impedance-pH data

Table 3 Correlation coefficients (by Spearman’s rank R) between the results of 24-h multichannel intraluminal impedance-pH records and local expression of inflammatory cytokines

	No. of GERs	Acid GERs	Weak-acid GERs	Non-acid GERs	High GERs	Mean pH	AET
IL-1β	-0.02	0.14	-0.11	0.04	-0.03	-0.24	0.29a
IL-10	-0.15	-0.02	-0.16	0.02	0.01	-0.21	0.18
IL-18	0.01	0.06	-0.02	0.01	0.01	-0.28a	0.31a
TNFA	-0.03	0.08	-0.12	0.01	-0.12	-0.33a	0.35a
GATA3	0.04	0.15	-0.13	-0.1	0.02	-0.28a	0.34a
TLR4	-0.05	0.04	-0.15	0.06	-0.04	-0.28a	0.29a
CD68	0.01	0.05	-0.03	-0.01	-0.08	-0.39a	0.37a
B2M	0.04	0.10	-0.04	0.17	0.09	-0.26	0.34a

^aP < 0.05: Marked values are statistically significant.

GERs: Gastroesophageal refluxes; AET: Acid exposure time (proportion of time with pH < 4 per 24 h at 5 cm above upper border of lower esophageal sphincter); mean pH: Mean values of pH at 5 cm above upper border of lower esophageal sphincter; IL-1β: Interleukin 1β; IL-10: Interleukin 10; IL-18: Interleukin 18; TNFA: Tumor necrosis factor α; TLR4: Toll-like receptor 4; GATA3: GATA binding protein 3; CD68: Differentiation cluster 68; B2M: β-2 microglobulin.