Local inflammatory response to gastroesophageal reflux: Association of gene expression of inflammatory cytokines with esophageal multichannel intraluminal impedance-pH data

Table 2 The results of gene expression analysis in groups of erosive esophagitis and non-erosive form of gastroesophageal reflux disease

	Control, n = 10	EE, n = 20	NERD, n = 40
IL-1β, log, mean ± SD	1.1 ± 0.2b,c	3.7 ± 0.4	3.8 ± 0.6
IL-10, log, mean ± SD	0.9 ± 0.1	1.4 ± 1.1	1.5 ± 1.8
IL-18, log, mean ± SD	2.1 ± 0.3b,c	5.9 ± 0.4	5.3 ± 1.1a
TNFA, log, mean ± SD	0.2 ± 0.1b,c	3.2 ± 0.4	3.1 ± 0.9
TLR4, log, mean ± SD	0.9 ± 0.2b,c	2.6 ± 0.7	2.5 ± 1.2
GATA3, log, mean ± SD	1.9 ± 0.2b	2.9 ± 0.9	2.2 ± 1.0a
CD68, log, mean ± SD	3.2 ± 1.3c	4.9 ± 0.6	5.0 ± 1.1
B2M, log, mean ± SD	4.0 ± 1.2	5.6 ± 0.6	5.5 ± 1.1

^aP < 0.05 vs erosive esophagitis group.

^bP < 0.05 vs group erosive esophagitis.

^cP < 0.05 vs group non-erosive form of gastroesophageal reflux disease.

EE: Erosive esophagitis; NERD: Non-erosive form of gastroesophageal reflux disease; SD: Standard deviation; IL-1β: Interleukin 1β; IL-10: Interleukin 10; IL-18: Interleukin 18; TNFA: Tumor necrosis factor α; TLR4: Toll-like receptor 4; GATA3: GATA binding protein 3; CD68: Differentiation cluster 68; B2M: β-2 microglobulin.