Early diagnostic value of liver stiffness measurement in hepatic sinusoidal obstruction syndrome induced by hematopoietic stem cell transplantation

Table 2 New European society for Blood and Marrow Transplantation criteria for severity grading of a suspected sinusoidal obstruction syndrome in adults

	Mild	Moderate	Severe	Very severe - MOD/MOF
Time since first clinical symptoms of SOS/VOD	> 7 d	5-7 d	≤ 4 d	Any time
Bilirubin (mg/dL)	≥ 2 and < 3	≥ 3 and < 5	≥ 5 and < 8	≥ 8
Bilirubin (μmol/L)	≥ 34 and < 51	≥ 51 and < 85	≥ 85 and < 136	≥ 136
Bilirubin kinetics			Doubling within 48 h
Transaminases	≤ 2 ULN	> 2 and ≤ 5 ULN	> 5 and ≤ 8 ULN	> 8 ULN
Weight increase	< 5%	≥ 5% and < 10%	≥ 5% and < 10%	≥ 10%
Renal function	< 1.2 × baseline at transplant	≥ 1.2 and < 1.5 × baseline at transplant	≥ 1.5 and < 2 × baseline at transplant	≥ 2 × baseline at transplant

MOD: Multi-organ dysfunction; MOF: Multi-organ failure; SOS: Sinusoidal obstruction syndrome; VOD: Veno-occlusive disease; ULN: Upper limit of normal.