Endometrial squamous cell carcinoma originating from the cervix: A case report

Figure 2 Microscopic appearance of the disease. A and B: Hematoxylin–eosin staining of the cervix (A) and endometrium (B). While it was a high-grade squamous intraepithelial lesion in the cervix (blue arrow), the lesion penetrated into the endometrium and the myometrium, forming squamous cell carcinoma in the uterine cavity (orange arrow); C-F: Immunohistochemical staining of the uterus. Both the cervix (C) and endometrium (D) showed strong expression of p16 (arrow), p63 was also highly expressed in the endometrium (E), whereas expression of estrogen receptor was negative in the endometrium, and normal endometrial glands (arrow) could also be seen (F).