Which octogenarian patients are at higher risk after cholecystectomy for symptomatic gallstone disease? A single center cohort study

Table 4 Univariate and multivariate analysis for postoperative complications with Clavien-Dindo grade > 2

Variables	Univariate analysis	P value	Multivariate analysis	P value
	OR (95%CI)		OR (95%CI)
Age	1.08 (0.98-1.18)	0.122
Sex	0.64 (0.30-1.38)	0.255
ASA
1	NA
2	0.14 (0.02-1-12)	0.064
3	Ref.	1
4	6.14 (2.48-15.3)	0.001	12.6 (4.27-37.3)	< 0.0001
BMI	1.12 (1.00-1.26)	0.05
CCI	1.19 (0.87-4.21)	0.237
Prior upper abdomen surgery	1.92 (0.72-5.12)	0.193
Leucocytes	1.00 (1.00-1.01)	0.021
Platelets	1.00 (1.00-1.00)	0.545
Bilirubin	1.37 (0.44-4.28)	0.014	1.41 (1.33-1.75)	0.002
C-reactive protein	1.00 (0.99-1.01)	0.252
Antiplatelet	0.96 (0.44-2.08)	0.916
Anticoagulant therapy	2.03 (0.91-4.53)	0.083
Acute cholecystitis Tokyo grade
Mild	3.33 (0.71-15.7)	0.128
Moderate	3.38 (0.86-13.2)	0.08
Severe	8.02 (2.21-29.0)	0.001
Biliary colic	0.79 (0.33-1.87)	0.599
Biliary pancreatitis	0.26 (0.03-1.98)	0.194
Choleperitoneum	2.89 (1.05-7.95)	0.039
Cholangitis	1.37 (0.44-4.28)	0.579
Preoperative ERCP	0.74 (0.16-3.33)	0.696
Admission-surgery interval	1.05 (0.99-1.11)	0.115
Laparoscopy	0.18 (0.08-0.40)	< 0.001
Conversion to open surgery	1.81 (0.75-4.35)	0.185
Choledocholithotomy	4.58 (1.45-14.5)	0.009	10.2 (2.04-51.1)	0.005
Transcystic biliary decompression	5.81 (2.20-15.4)	0.0004
Intraoperative cholangiography	0.86 (0.40-1.86)	0.706
Intraoperative ERCP	1.38 (0.44-4.28)	0.579
Afternoon night procedure	1.82 (0.84-3.91)	0.126

ASA: American Society of Anesthesiologists; BMI: Body mass index; ERCP: Endoscopic retrograde cholangio-pancreatography; CCI: Charlson comorbidity index; NA: Not available.