Which octogenarian patients are at higher risk after cholecystectomy for symptomatic gallstone disease? A single center cohort study

Table 3 Univariate and multivariate analysis for postoperative complications

Variables	Univariate analysis	P value	Multivariate analysis	P value
	OR (95%CI)		OR (95%CI)
Age	1.00 (0.93-1.08)	0.864
Sex	0.85 (0.50-1.46)	0.562
ASA
1	NA	NA
2	0.51 (0.28-0.93)	0.027
3	Ref.	1
4	9.53 (1.26-72.1)	0.029
BMI	0.92 (0.85-1.01)	0.072
CCI	0.82 (0.43-1.60	0.611
Prior upper abdomen surgery	0.79 (0.36-1.72)	0.559
Leucocytes	1.00 (1.00-1.00)	0.009
Platelets	1.00 (1.00-1.00)	0.013	1.00 (1.00-1.00)	0.0008
Bilirubin	1.23 (0.97-1.57)	0.081
C-reactive protein	1.00 (0.99-1.00)	0.195
Antiplatelet	1.33 (0.77-2.31)	0.311
Anticoagulant therapy	1.922 (0.96-3.85)	0.065
Acute cholecystitis Tokyo grade
Mild	1.55 (0.67-3.35)	0.324
Moderate	2.19 (1.11-4.32)	0.023
Severe	4.54 (2.00-10.3)	0.0003
BIliary colic	3.43 (1.70-6.93)	0.0006
Biliary pancreatitis	1.24 (0.51-3.04)	0.635
Gallbladder cancer	1.95 (0.22-17.1)	0.543
Choleperitoneum	1.61 (0.58-4.45)	0.36
Cholangitis	12.0 (1.59-89.7)	0.019	12.7 (1.61-100.1)	0.016
Preoperative ERCP	0.38 (0.16-0.91)	0.03
Admission-surgery interval	1.04 (0.95-1.14)	0.326
Laparoscopy	0.28 (0.11-0.69)	0.005	0.10 (0.02-0.46)	0.003
Conversion to open surgery	1.81 (0.37-1.42)	0.354
Choledocholithotomy	1.07 (0.33-3.46)	0.914
Intraoperative cholangiography	2.12 (1.23-3.64)	0.007	2.99 (1.43-6.24)	0.003
Intraoperative ERCP	1.47 (0.57-3.78)	0.423
Transcystic biliary decompression	2.57 (0.73-8.95)	0.138
Afternoon night procedure	2.12 (1.21-3.74)	0.009

ASA: American Society of Anesthesiologists; BMI: Body mass index; ERCP: Endoscopic retrograde cholangio-pancreatography; CCI: Charlson comorbidity index; NA: Not available.