Which octogenarian patients are at higher risk after cholecystectomy for symptomatic gallstone disease? A single center cohort study

Table 1 Patients’ characteristics and their comparison according to the occurrence of postoperative complications

Variables	Total cohort (n = 269)	Uncomplicated (n = 76)	Complicated (n = 193)	P value
Age	83	83 (82-85)	83 (82-87)	0.686
Sex (M:F)	126:143	344:200	92:101	0.686
ASA
1	1 (0.0)	0	1 (0.5)	0.002
2	62 (23.0)	27 (35.5)	35 (18.1)
3	179 (66.5)	48 (63.2)	131 (67.9)
4	27 (10.0)	1(1.3)	26 (13.5)
BMI	24.8 (24-25.1)	26.3 (22.9-28.2)	24.2 (21.1-27.4)	0.062
Charlson comorbidity index	3 (1-4)	3 (2-4)	2 (1-4)	0.145
Prior upper abdomen surgery	34 (12.6)	11 (32.3)	23 (67.7)	0.548
Leucocytes (× 109/L)	11685 (10520-12957)	9300 (7315-13917)	12850 (8020-18200)	0.009
Platelets (× 109/L)	236 (183-352)	197 (165-262)	272 (189-340)	< 0.0001
Bilirubin (mg/dL)	1.01 (0.58-1.91)	0.82 (0.41-1.53)	1.11 (0.62-2.1)	0.011
C-reactive protein (mg/L)	82 (19.7-225)	46.4 (9-184.6)	85.7 (22.2-231.0)	0.135
Antiplatelet	110 (40.9)	28 (36.8)	82 (42.5)	0.412
Anticoagulant therapy	64 (23.8)	12 (15.8)	52 (26.9)	0.057
Acute cholecystitis Tokyo grade				0.147
Mild	36 (20.1)	11(14.5)	25 (13)
Moderate	75 (42.0)	18 (23.7)	57 (29.6)
Severe	68 (37.9)	10 (13.2)	58 (30.0)
Diagnosis at admission in urgency				0.374
A.C.	69 (38.5)	19 (27.6)	50 (72.4)
A.C. + cholangitis	19 (10.6)	1 (5.2)	18 (94.8)
A.C. + choleperitoneum	25 (14.0)	5 (20)	20 (80)
A.C. + biliary colic	38 (21.2)	9 (23.7)	29 (76.3)
A.C. + biliary pancreatitis	28 (15.7)	7 (25)	21(75)
Preoperative ERCP	23 (8.6)	11 (14.5)	12 (6.2)	0.053
Admission-surgery interval	1 (0-2)	1 (0-2)	1 (0-3)	0.051
Operative time (min)	100 (73-141)	90 (66-120)	105 (75-150)	0.021
Surgical approach				0.012
Laparoscopy		53	115
Open		6 (7.9)	46 (23.8)
Converted to open		17 (23.4)	32(16.6)
Intraoperative cholangiography	161 (58.9)	35 (46.1)	126 (65.3)	0.0005
Choledocholithotomy	15 (5.6)	4 (5.3)	11 (5.7)	1
Transcystic biliary decompression	22 (8.2)	3 (3.9)	19 (9.8)	0.147
Intraoperative ERCP	28 (10.4)	6 (7.9)	22 (11.4)	0.508
Afternoon night-procedure	117 (43.5)	24 (31.6)	93(48.2)	0.014
Length of hospital stay	5 (3-8)	3 (2-6)	6 (4-9)	< 0.0001
Supported discharge	47 (17.5)	9 (11.9)	38 (19.7)	0.154

ASA: American Society of Anesthesiologists; BMI: Body mass index; A.C.: Acute cholecystitis; ERCP: Endoscopic retrograde cholangio-pancreatography.