Identification of predictive factors for post-transarterial chemoembolization liver failure in hepatocellular carcinoma patients: A retrospective study

Table 2 Univariate and multivariate logistic models for identifying risk factors of post-transarterial chemoembolization liver failure¹

Variables	Univariate		P value	Multivariate		P value
	OR	95%CI		OR	95%CI
Microsphere plus gelatin embolization, yes vs no	8.0	2.8-22.7	< 0.001	4.4	1.2-16.3	0.027
Combination with RFA, yes vs no	0.3	0.1-0.9	0.035	0.3	0.1-1.2	0.094
Main tumor size ≥ 5 cm, yes vs no	2.1	1.2-3.8	0.014	2.3	1.05-5.3	0.039
Resection history, yes vs no	0.4	0.2-0.9	0.034	0.4	0.2-0.95	0.039
Diabetes, yes vs no	0.4	0.2-1.1	0.084	0.3	0.1-1.03	0.056
Hematocrit, per increase 1%	1.1	1.0-1.1	0.034	1.1	0.997-1.1	0.06
ALT, per increase 1 U/L	1.01	1.0-1.03	0.026	1.01	0.99-1.03	0.262
AST, per increase 1 U/L	1.0	1.0-1.01	0.074	0.99	0.98-1.004	0.177
GGT, per increase 1 U/L	1.0	1.0-1.0	0.08	1.0	1.0-1.0	0.499
TBiL, μmol/L
Normal	Reference	-	1.0	Reference	-	1.0
1-2 ULN	1.8	1.0-3.5	0.065	1.8	0.8-4.2	0.163
≥ 2 ULN	2.3	1.0-5.3	0.062	2.1	0.6-7.5	0.269
DBiL, per increase 1 μmol/L	1.8	1.0-3.2	0.054	0.99	0.96-1.02	0.718
TBA ≥ 17.7μmol/L, yes vs no	1.8	1.0-3.3	0.044	1.6	0.7-3.5	0.263
Serum cystatin C, per increase 1 mg/L	0.4	0.1-1.0	0.041	0.6	0.1-3.6	0.584
Creatinine, per increase 1 μmol/L	0.98	0.97-1.0	0.048	0.99	0.95-1.02	0.499
eGFR, per increase 1 ml/(min∙1.73 m2)	1.01	1.0-1.02	0.033	1.0	0.98-1.02	0.81

¹Only variables significantly associated with post-transarterial chemoembolization liver failure in univariate analysis (P < 0.10) were presented.

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; direct bilirubin; eGFR: Estimated glomerular filtration rate; GGT: Gamma-glutamyl transferase; RFA: Radiofrequency ablation; TBA: Total bile acid; TBiL: Total bilirubin; ULN: Upper limit of normal; OR: Odds ratio; CI: Confidence interval.