Same-day single-dose vs large-volume split-dose regimens of polyethylene glycol for bowel preparation: A systematic review and meta-analysis

Table 3 Secondary outcome

Secondary outcome	Studies (n)	SSD (n)	SpDs (n)	I2 (%)	P value for heterogeneity	Pooled analysis (cat-RR/con-MD)	95%CI	P value
Sleep disturbance	15	2591	2463	74	< 0.00001	0.52	(0.40, 0.68)	< 0.00001
2 L SSD with adjuvant vs SpDs	7	1214	1215	69	0.003	0.69	(0.43, 1.10)	0.12
2 L SSD without adjuvant vs SpDs	6	1014	1013	80	0.0002	0.45	(0.30, 0.67)	< 0.0001
4 L SSD without adjuvant vs SpDs	3	363	375	67	0.05	0.47	(0.28, 0.78)	0.004
Willingness to repeat	10	1996	1855	90	< 0.00001	1.15	(1.03, 1.29)	0.01
2 L SSD with adjuvant vs SpDs	6	1073	1078	89	< 0.00001	1.24	(1.06, 1.45)	0.008
2 L SSD without adjuvant vs SpDs	3	691	690	82	0.004	1.14	(1.01, 1.29)	0.03
4 L SSD without adjuvant vs SpDs	2	232	227	54	0.14	0.89	(0.71, 1.13)	0.34
Side effects
Nausea	17	2715	2592	68	< 0.0001	0.95	(0.78, 1.16)	0.63
Vomiting	16	2644	2521	64	0.0002	0.96	(0.66, 1.38)	0.81
Abdominal pain	17	2715	2592	38	0.06	0.75	(0,62, 0.90)	0.002
Bloating	15	2205	2077	67	0.0001	0.80	(0.63, 1.01)	0.06

SSD: Same-day single-dose; SpDs: Split-dose; cat-RR/con-MD: Categorical-relative risk ratio/continuous-mean differences; CI: Confidence interval.