Application of metagenomic next-generation sequencing in the diagnosis of infectious diseases of the central nervous system after empirical treatment

Table 7 The results of meningitis in all patients were compared between the two methods

	Sensitivity	Specificity	Accuracy	Positive predictive value	Negative predictive value
Conventional methods	37.2% (30.2%, 44.6%)	85.1% (73.8%, 92.2%)	50.0% (43.7%, 56.3%)	87.2% (77.2%, 83.3%)	33.1% (26.3%, 40.8%)
mNGS	65.6% (58.2%, 72.3%)	89.6% (79.1%, 95.3%)	72.0% (65.9%, 77.4%)	94.5% (88.6%, 97.6%)	48.8% (39.7%, 57.9%)
P value	< 0.001	0.436	< 0.001	0.065	0.007

mNGS: Metagenomic next-generation sequencing.