Application of metagenomic next-generation sequencing in the diagnosis of infectious diseases of the central nervous system after empirical treatment

Table 5 Performance of metagenomic next-generation sequencing and the conventional methods in the diagnosis of central nervous system fungal infections

	Sensitivity	Specificity	Accuracy	Positive predictive value	Negative predictive value
Conventional methods	44.4% (26.0%, 64.4%)	83.3% (36.5%, 99.1%)	51.5% (33.9%, 68.8%)	92.3% (62.1%, 99.6%)	25.0% (9.6%, 49.4%)
mNGS	63.0% (42.5%, 79.9%)	100.0% (51.7%, 100.0%)	69.7% (51.1%, 83.8%)	100.0% (77.1%, 100.0%)	37.5% (16.3%, 64.1%)
P value	0.172	1.000	0.131	0.433	0.656