Application of metagenomic next-generation sequencing in the diagnosis of infectious diseases of the central nervous system after empirical treatment

Table 3 Performance of metagenomic next-generation sequencing and the conventional methods in the diagnosis of central nervous system bacterial infections

	Sensitivity	Specificity	Accuracy	Positive predictive value	Negative predictive value
Conventional methods+	14.3% (8.5%, 23.6%)	84.6% (64.3%, 95.0%)	33.3% (24.2%, 43.8%)	71.4% (42.0%, 90.4%)	26.8% (17.9%, 37.9%)
mNGS+	65.7% (53.3%, 76.4%)	88.5% (68.7%, 97.0%)	71.9% (61.6%, 80.3%)	93.9% (82.1%, 98.4%)	48.9% (34.3%, 63.7%)
P value	< 0.001	1.000	< 0.001	0.061	0.011