Application of metagenomic next-generation sequencing in the diagnosis of infectious diseases of the central nervous system after empirical treatment

Table 1 The performance of metagenomic next-generation sequencing and the conventional methods in the diagnosis of central nervous system virus infections

	Sensitivity	Specificity	Accuracy	Positive predictive value	Negative predictive value
Conventional methods+	53.5% (42.7%, 64.2%)	85.7% (69.0%, 94.6%)	62.8% (53.5%, 71.3%)	90.2% (77.8%, 96.3%)	42.9% (31.3%, 55.2%)
mNGS+	66.3% (55.2%, 75.9%)	88.6% (72.3%, 96.3%)	72.7% (63.7%, 80.2%)	93.4% (83.3%, 97.9%)	51.7% (38.5%, 64.6%)
P value	0.087	1.000	0.099	0.779	0.316