Programmed cell death-1 inhibitor combination treatment for recurrent proficient mismatch repair/ miscrosatellite-stable type endometrial cancer: A case report

Figure 1 Pathological examination of pulmonary biopsy of the patient. The Hematoxylin-eosin staining and immunohistochemistry staining results indicated that the endometrioid adenocarcinoma had metastasized to the lung. A: A hematoxylin and eosin-stained slide showed the glands are arranged back-to-back and crowded, with complex branches. Parts of them form papillary structures into the glandular lumen, with only a small amount of stroma. The glandular epithelium is stratified with no polar orientation. The nuclei tend to be round. The nuclear to cytoplasmic ratio was increased, the chromatin were vacuolated, and nucleoli could be seen; B: Estrogen receptor staining showing diffuse estrogen receptor expression; C: Progesterone receptor staining showing diffuse nuclear progesterone receptor expression; D: Thyroid transcription factor-1 (TTF-1) immunohistochemistry showing negative TTF-1 staining in the nucleus; E: Napsin A immunohistochemistry showing negative Napsin A staining in the cytoplasm. Original magnification: 100 ×; scale bar: 100 μm.