Programmed cell death-1 inhibitor combination treatment for recurrent proficient mismatch repair/ miscrosatellite-stable type endometrial cancer: A case report

doi:10.12998/wjcc.v10.i21.7474

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Jul 26, 2022 (publication date) through Nov 4, 2024

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World Journal of Clinical Cases

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World J Clin Cases. Jul 26, 2022; 10(21): 7474-7482
Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7474

Table 1 Genetic testing of blood and tissue samples

Tests	Results
Next generation sequencing
PD-L1 expression	Negative
Mismatch repair	pMMR
Tumor mutation burden	2.09 Muts/Mb
MicroSatelite Instability	MSS
Human leukocyte antigen typing	Heterogeneous
Tumor neoantigens	6
POLE	Negative
TP53	Negative
Predictive/prognostic biomarkers
MDM4	4 amplifications
AKT1	83.05% p. Glu17 Lys mutation
CTNNB1	37.06% p. Ser37Ala mutation

PD-L1: Programmed cell death-Ligand 1; POLE: Polymerase epsilon; TP: Tumor protein; MDM: Murine double minute; AKT: V-Akt murine thymoma viral oncogene homolog; CTNNB: Catenin beta; pMMR: Proficient mismatch repair; Mb: Mega byte; MSS: Miscrosatellite-stable.

Citation: Zhai CY, Yin LX, Han WD. Programmed cell death-1 inhibitor combination treatment for recurrent proficient mismatch repair/ miscrosatellite-stable type endometrial cancer: A case report. World J Clin Cases 2022; 10(21): 7474-7482
URL: https://www.wjgnet.com/2307-8960/full/v10/i21/7474.htm
DOI: https://dx.doi.org/10.12998/wjcc.v10.i21.7474