Expression of hepatocyte nuclear factor 4 alpha, wingless-related integration site, and β-catenin in clinical gastric cancer

doi:10.12998/wjcc.v10.i21.7242

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Clin Cases. Jul 26, 2022; 10(21): 7242-7255
Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7242

Table 4 Correlation of hepatocyte nuclear factor 4 alpha and wingless-related integration site expression with types of gastric carcinomas according to WHO classification

Groups	n	Grade of HNF4α expression				Grade of WNT5a expression
Groups	n	+ (%)	++ (%)	+++ (%)		+ (%)	++ (%)	+++ (%)
Tubular	35	4 (11.4)	2 (5.7)		29 (82.7)^b	2 (5.7)	11 (31.4)	22 (62.9)
Signet ring	59	5 (8.5)	11 (18.6)		43 (72.9)	4 (6.8)	17 (28.8)	38 (64.4)
Mucinous	64	4 (6.3)	7 (10.9)		53 (82.8)^b	3 (4.7)	10 (15.6)	51 (79.7)^d

^bP < 0.001 hepatocyte nuclear factor 4 alpha (χ²= 83.909) vs signet ring; ^dP < 0.001 wingless-related integration site (χ² = 105.865) vs tubular and signet ring. HNF4α: Hepatocyte nuclear factor 4 alpha; WNT5A: Wingless-related integration site.

Citation: Hu Q, Li LL, Peng Z, Yi P. Expression of hepatocyte nuclear factor 4 alpha, wingless-related integration site, and β-catenin in clinical gastric cancer. World J Clin Cases 2022; 10(21): 7242-7255
URL: https://www.wjgnet.com/2307-8960/full/v10/i21/7242.htm
DOI: https://dx.doi.org/10.12998/wjcc.v10.i21.7242