Molecular mechanisms of Biyu decoction as treatment for psoriasis: A network pharmacology and molecular docking study

doi:10.12998/wjcc.v10.i21.7224

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Clin Cases. Jul 26, 2022; 10(21): 7224-7241
Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7224

Table 2 Protein-protein interaction core network gene score

Name	Betweenness	Closeness	Degree	Eigenvector	LAC	Network
MAPK8	0.793650794	0.833333333	8	0.287379682	6.25	7.142857143
TP53	0.472222222	0.833333333	8	0.290343016	6.5	7.428571429
RELA	1.205555556	0.833333333	8	0.280704081	6	7.142857143
NFKBIA	0.222222222	0.714285714	6	0.217291564	4.666666667	5.6
STAT3	0.472222222	0.833333333	8	0.290343136	6.5	7.428571429
MAPK3	2.576984127	1	10	0.341228724	7.4	10
JUN	2.576984127	1	10	0.341228724	7.4	10
MAPK1	2.354761905	0.909090909	9	0.30924511	6.444444444	7.978571429
FOS	1.043650794	0.909090909	9	0.31924358	7.111111111	8.482142857
MAPK14	2.354761905	0.909090909	9	0.30924511	6.444444444	7.978571429
MYC	1.926984127	0.909090909	9	0.311044633	6.666666667	8.196428571

LAC: Local average connectivity.

Citation: Wang Z, Zhang HM, Guo YR, Li LL. Molecular mechanisms of Biyu decoction as treatment for psoriasis: A network pharmacology and molecular docking study. World J Clin Cases 2022; 10(21): 7224-7241
URL: https://www.wjgnet.com/2307-8960/full/v10/i21/7224.htm
DOI: https://dx.doi.org/10.12998/wjcc.v10.i21.7224