Clinical features and genetic variations of severe neonatal hyperbilirubinemia: Five case reports

Table 1 Clinical and laboratory characteristics of five neonates with severe hyperbilirubinemia

Case ID	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5
Gender	Male	Male	Male	Female	Male
Admission time (d)	5	12	4	28	7
Gestational age (wk)	39 + 5	39	40 + 3	40	35 + 4
Birth weight (kg)	3.15	3.1	3.3	3.25	2.65
Mode of delivery	Vaginal	Cesarean	Cesarean	Cesarean	Vaginal
Feeding patterns	Formula	Breast	Breast	Formula	Breast
Postnatal growth ratardation	+	-	-	+	-
Skin and mucous membrane yellowing	+	+	+	+	+
Time of jaundice occur after birth (d)	2	3	3	4	2
Maximum TBIL levels (μmol/L)a	719.5	527.87	429.6	538.7	584.4
Age at maximum TBIL (d)	5	12	4	28	7
Phototherapy	+	+	+	+	+
RBC transfusion	-	+	-	-	-
IVIGb or albumin therapy	+	+	+	-	-
Clinical diagnosis	G6PD deficiency; Congenital hypertrophic pyloric stenosis; Neonatal hyperbilirubinemia	G6PD deficiency; Anemia; Bilirubin encephalopathy	ABO blood type incompatibility hemolytic disease	Congenital hypothyroidism; Neonatal hyperbilirubinemia	Premature delivery; Neonatal hyperbilirubinemia

^aNormal upper limit: 20.1 µmol/L.

^bIntravenous immunoglobulin.

+: Present; -: Absent; TBIL: Total bilirubin; RBC: Red blood cell; IVIG: Intravenous immunoglobulin; G6PD: Glucose-6-phosphate dehydrogenase.