Schwannomatosis patient who was followed up for fifteen years: A case report

Table 2 Diagnosis of schwannomatosis based on molecular and/or clinical diagnostic criteria according to Plotkin et al[18]

Clinical diagnosis	Combined molecular and clinical diagnosis	Exclusion criteria
≥ 2 nonintradermal schwannomas, 1 pathologically confirmed schwannoma and absence of bilateral vestibular schwannomas Or 1 pathologically confirmed schwannoma or intracranial meningioma and 1 affected first-degree relative	≥ 2 pathologically confirmed schwannomas or meningiomas; ≥ 2 tumors with 22q LOH and 2 different somatic NF2 mutations Or 1 pathologically confirmed schwannoma or meningioma; Germline SMARCB1 or LZTR1 pathogenic mutation	Germline pathogenic NF2 mutation; Diagnostic criteria for NF2 fulfilled; First-degree relative with NF2; Schwannomas occur exclusively in a region of previous radiation therapy