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©The Author(s) 2022.
World J Clin Cases. Jul 16, 2022; 10(20): 6944-6953
Published online Jul 16, 2022. doi: 10.12998/wjcc.v10.i20.6944
Published online Jul 16, 2022. doi: 10.12998/wjcc.v10.i20.6944
Table 4 Shows the studies on twins harboring 11778 and 14484 Leber’s hereditary optic neuropathy mutation
| Ref. | Mono/dizygotic twin (Sex) | Homo/heteroplsmy | Dis-cordant | Age at onset/onset time difference (year) | Epigenetic factors |
| 11778 | |||||
| Nikoskelainen et al[7,8], 1987 | NA (m) | Homoplasmy | No | 20/NA | NA |
| Newman et al[9], 1991 | M (m) | NA | Yes | NA | NA |
| D (m, f) | NA | Yes | NA | ||
| Johns et al[2], 1993 | M (m) | Homoplasmy | No | 34/11 | Alcohol/tobacco use |
| 14484 | |||||
| Biousse et al[11], 1997 | M (m) | Heteroplasmy | Yes | 17/ NA | None |
| Current study 2021 | M (m) | Homoplasmy | Yes | 34/ NA | Alcohol/tobacco use |
- Citation: Chuenkongkaew WL, Chinkulkitnivat B, Lertrit P, Chirapapaisan N, Kaewsutthi S, Suktitipat B, Mitrpant C. Clinical expression and mitochondrial deoxyribonucleic acid study in twins with 14484 Leber’s hereditary optic neuropathy: A case report . World J Clin Cases 2022; 10(20): 6944-6953
- URL: https://www.wjgnet.com/2307-8960/full/v10/i20/6944.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v10.i20.6944