Network pharmacology-based strategy for predicting therapy targets of Sanqi and Huangjing in diabetes mellitus

Table 4 Kyoto encyclopedia of genes and genomes pathway analysis based on target-pathway network

Pathway ID	Pathway name	Count	P value	Gene name
05140	Leishmaniasis	9	5.61E-10	IL-10, IL-1A, TGFB1, NCF1, NOS2, STAT1, MAPK1, PTGS2, TNF
05200	Pathways in cancer	13	5.36E-08	GSK3B, TGFB1, NOS2, PRKCB, STAT1, MMP1, MMP2, PTGS2, CCND1, MYC, BCL2, MAPK1, PPARD
05161	Hepatitis B	8	2.75E-06	TGFB1, CCND1, STAT1, PRKCB, MYC, BCL2, MAPK1, TNF
05210	Colorectal cancer	6	7.16E-06	GSK3B, TGFB1, CCND1, MYC, BCL2, MAPK1
05145	Toxoplasmosis	7	7.75E-06	IL-10, TGFB1, NOS2, STAT1, BCL2, MAPK1, TNF
04919	Thyroid hormone signaling pathway	7	1.00E-05	GSK3B, CCND1, STAT1, PRKCB, MYC, MAPK1, ESR1
05152	Tuberculosis	8	1.03E-05	IL-10, IL-1A, TGFB1, NOS2, STAT1, BCL2, MAPK1, TNF
05133	Pertussis	6	1.83E-05	IL-10, IL-1A, NOS2, CASP1, MAPK1, TNF
05205	Proteoglycans in cancer	8	2.30E-05	TGFB1, CCND1, PRKCB, MYC, MMP2, MAPK1, ESR1, TNF
05146	Amoebiasis	6	9.76E-05	IL-10, TGFB1, NOS2, PRKCB, HSPB1, TNF
05164	Influenza A	7	1.05E-04	IL-1A, GSK3B, STAT1, PRKCB, CASP1, MAPK1, TNF
04380	Osteoclast differentiation	6	2.65E-04	IL-1A, TGFB1, NCF1, STAT1, MAPK1, TNF
04010	MAPK signaling pathway	7	7.91E-04	IL-1A, TGFB1, PRKCB, MYC, HSPB1, MAPK1, TNF