Intrathecal methotrexate in combination with systemic chemotherapy in glioblastoma patients with leptomeningeal dissemination: A retrospective analysis

Figure 2 Magnetic resonance imaging scans (T1 + gadolinium) of a patient before (upper panel) and after 4 cycles of vp-16 + CBP chemotherapy combination with methotrexate intrathecal injection (lower panel). The lesion in the right temporal lobe was stable after surgery. The multiple lesions in the cervical (middle column, red arrows) and lumbar (right column, red arrows) spine went into remission.