Intrathecal methotrexate in combination with systemic chemotherapy in glioblastoma patients with leptomeningeal dissemination: A retrospective analysis

Figure 1 Kaplan-Meier survival curve from leptomeningeal dissemination diagnosis according to treatment. A: Overall survival (OS) of all leptomeningeal dissemination (LMD) patients; B: OS of patients with gross total resection of the tumor or not [median 24.7, 95%CI (15.1, 34.3) vs 10.9, 95%CI (8.0, 13.7), P = 0.022]; C: Difference between KPS > 60 and KPS ≤ 60 (16 mo and 9 mo, respectively, P = 0.002); D: Difference between Ommaya reservoir implant or not (15 mo vs 6 mo, P < 0.001).