Hepatic epithelioid hemangioendothelioma: Clinical characteristics, diagnosis, treatment, and prognosis

Table 3 Results of univariable and multivariate analysis

Parameter	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Sex, male/female	1.175 (0.549-2.513)	0.678
Age, > 45 yr/≤ 45 yr	0.952 (0.447-2.027)	0.898
Symptoms, symptomatic/asymptomatic	3.047 (0.911-10.185)	0.070
AFP, elevated/normal	1.261 (0.555-2.863)	0.579
Liver function, abnormal/normal	2.720 (1.236-5.988)	0.013	2.258 (1.017-5.009)	0.045
Maximum diameter of tumor, ≥ 5 cm/< 5 cm	2.430 (0.856-6.901)	0.096
Intrahepatic metastasis, yes/no	3.553 (1.228-10.277)	0.019	3.930 (1.152-13.404)	0.029
Extrahepatic metastasis, yes/no	2.328 (1.065-5.089)	0.034		0.558
Treatments, nonsurgical treatment/surgical treatment	2.831 (1.195-6.704)	0.018	2.591 (1.022-6.565)	0.045

HR: Hazard ratio; CI: Confidence interval; AFP: Alpha fetoprotein.