Idiopathic membranous nephropathy in children: A case report

Figure 1 Representative images of pathological changes on renal biopsy. Diffuse thickening of the basement membrane with several spiky formations, subepithelial deposition of fuchsinophilic protein, and vacuolar and granular degeneration of renal tubular epithelial cells were observed. A: Light microscopy (Periodic acid-Schiff, × 400); B: Light microscopy (Periodic acid-silver methenamine, × 400); C: Light microscopy (Masson staining, × 400); D-F: Irregular thickening of the basement membrane, electron-dense deposits in the subepithelial and intrabasal areas, and diffuse fusion of the foot processes (electron microscopy, × 6000); G: Depositions of immunoglobulin G (IgG) along the mesangial area and the capillary wall (immunohistochemical staining, × 400); H: Depositions of IgG₁ along the mesangial area and the capillary wall (immunohistochemical staining, × 400); I: Depositions of IgG₄ along the mesangial area and the capillary wall. Positivity for phospholipase A₂ receptor and negativity for thrombospondin type-1 domain-containing 7A are shown (immunohistochemical staining, × 400).