Circulating miR-627-5p and miR-199a-5p are promising diagnostic biomarkers of colorectal neoplasia

Figure 2 Evaluation of the diagnostic utility of circulating cell-free miR-627 and miR-199a-5p in the GSE25069 dataset. A: Plasma expression of miR-627 and miR-199a-5p in healthy controls (HCs), advanced colorectal adenoma (AA) and colorectal cancer (CRC) patients; B: Receiver operating characteristic analysis of miR-627 and miR-199a-5p to distinguish patients with CRC and AA from HCs. Circulating levels of miR-627 discriminate CRC patients from controls with an area under the curve (AUC) = 0.69. MiR-199a-5p discriminated the AA group from control group with an AUC = 0.69. ^aP < 0.05. NS: Not significant; HC: Healthy control; AA: Advanced colorectal adenoma; CRC: Colorectal cancer; AUC: Area under the curve.