Copyright
©The Author(s) 2022.
World J Clin Cases. Jun 6, 2022; 10(16): 5253-5265
Published online Jun 6, 2022. doi: 10.12998/wjcc.v10.i16.5253
Published online Jun 6, 2022. doi: 10.12998/wjcc.v10.i16.5253
Variable | Chemotherapy (n = 470), n (%) | BSC (n = 652), n (%) | P value |
Age | |||
Young (age < 75 yr) | 375 (79.8) | 335 (51.4) | < 0.001 |
Elder (age ≥ 75 yr) | 95 (20.2) | 317 (48.6) | |
Sex | |||
Male | 284 (60.4) | 363 (55.7) | 0.112 |
Female | 186 (39.6) | 289 (44.3) | |
Charlson co-morbidity index score | |||
< 3 | 175 (37.2) | 343 (52.6) | < 0.001 |
≥ 3 | 295 (62.8) | 309 (47.4) | |
Barthel index | |||
≥ 60 | 422 (89.8) | 436 (66.9) | < 0.001 |
< 60 | 27 (5.7) | 153 (23.5) | |
Missing | 21 (4.5) | 63 (9.7) | |
Medication | |||
Aspirin | 18 (3.8) | 33 (5.1) | 0.329 |
Thienopyridine | 7 (1.5) | 24 (3.7) | 0.027 |
Warfarin | 8 (1.7) | 20 (3.1) | 0.148 |
DOACs | 34 (7.2) | 29 (4.4) | 0.045 |
Other antiplatelet drugs | 7 (1.5) | 33 (5.1) | 0.001 |
NSAIDs | 293 (62.3) | 314 (48.2) | < 0.001 |
Steroids | 201 (42.8) | 154 (23.6) | < 0.001 |
Cancer type | |||
Esophageal cancer | 24 (5.1) | 83 (12.7) | < 0.001 |
Gastric cancer | 151 (32.1) | 113 (17.3) | |
Pancreatic cancer | 69 (14.7) | 106 (16.3) | |
Colorectal cancer | 146 (31.1) | 212 (32.5) | |
Other cancers | 80 (17.0) | 138 (21.2) | |
Cancer stage | |||
Stage I-III | 81 (17.2) | 157 (24.1) | 0.022 |
Stage IV or recurrence | 297 (63.2) | 379 (58.1) | |
Missing | 92 (19.6) | 116 (17.8) | |
Obstruction site | |||
Esophageal obstruction | 38 (8.1) | 105 (16.1) | < 0.001 |
Gastroduodenal obstruction | 189 (40.2) | 233 (35.7) | |
Lower gastrointestinal obstruction | 243 (51.7) | 314 (48.2) | |
Chemotherapy before the intervention | 274 (58.3) | 413 (63.3) | 0.087 |
Intervention type | |||
Palliative surgery | 294 (62.6) | 283 (43.4) | < 0.001 |
SEMS placement | 176 (37.4) | 369 (56.6) |
- Citation: Fujisawa G, Niikura R, Kawahara T, Honda T, Hasatani K, Yoshida N, Nishida T, Sumiyoshi T, Kiyotoki S, Ikeya T, Arai M, Hayakawa Y, Kawai T, Fujishiro M. Effectiveness and safety of chemotherapy for patients with malignant gastrointestinal obstruction: A Japanese population-based cohort study. World J Clin Cases 2022; 10(16): 5253-5265
- URL: https://www.wjgnet.com/2307-8960/full/v10/i16/5253.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v10.i16.5253