Circulating miR-627-5p and miR-199a-5p are promising diagnostic biomarkers of colorectal neoplasia

Table 2 Diagnostic power of each marker for colorectal cancer and advanced adenoma

		AUC	Sensitivity	Specificity	Cut-off value	P value
CRC vs HC	miR-627-5p	0.97	0.87	1.00	2.21	< 0.001
	miR-199a-5p	0.90	0.93	0.70	1.79	< 0.001
	CEA	0.70	0.32	1.00	7.83	< 0.01
	CA199	0.54	0.12	1.00	42.50	0.52
	Integrated model	0.98	0.87	1.00	0.84	< 0.001
AA vs HC	miR-627-5p	0.84	0.62	0.93	1.87	< 0.001
	miR-199a-5p	0.76	0.90	0.53	1.35	< 0.001
	CEA	0.50	0.80	0.33	1.44	0.95
	CA199	0.43	1.00	0.04	1.31	0.27
	Integrated model	0.86	0.78	0.77	0.59	< 0.001
CRC+AA vs HC	miR-627-5p	0.90	0.77	0.93	1.87	< 0.001
	miR-199a-5p	0.83	0.81	0.70	1.78	< 0.001
	CEA	0.60	0.90	0.30	1.28	0.12
	CA199	0.49	0.07	1.00	42.50	0.80
	Integrated model	0.92	0.83	0.87	0.74	< 0.001

CRC: Colorectal cancer; AA: Advanced adenoma; HC: Healthy control; CA199: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen.