Circulating miR-627-5p and miR-199a-5p are promising diagnostic biomarkers of colorectal neoplasia

Table 1 Clinical characteristics of all patients with colorectal cancer, advanced adenoma and healthy controls

Factors		Phase II				Phase III
		CRC (n = 60)	AA (n = 60)	HC (n = 30)	P value	CRC (n = 30)	AA (n = 33)	HC (n = 20)	P value
Age (yr)		66.95 ± 10.52	62.70 ± 10.58	63.60 ± 7.60	0.06	65.40 ± 10.10	60.27 ± 10.07	61.40 ± 8.15	0.10
Gender	Male	41 (68.33%)	42 (70.00%)	20 (66.67%)	0.95	21 (70%)	25 (75.76%)	17 (85.00%)	0.48
	Female	19 (31.67%)	18 (30.00%)	10 (33.33%)		9 (30%)	8 (24.24%)	3 (15.00%)
Lymph node metastasis	Present	21 (35.00%)				9 (30%)
	Absent	39 (65.00%)				21 (70%)
TNM stage	I-II	37 (61.67%)				20 (66.67%)
	III-IV	23 (38.33%)				10 (33.33%)
Histology	SSA	0 (0%)	1 (1.67%)			0 (0%)	1 (3.03%)
	TA	0 (0%)	35 (58.33%)			0 (0%)	18 (54.55%)
	TVA	0 (0%)	24 (40.00%)			0 (0%)	14 (42.42%)
	Adenocarcinoma	60 (100%)				30 (100%)

CRC: Colorectal cancer; AA: Advanced adenoma; HC: Healthy control; SSA: Sessile serrated adenoma; TA: Tubular adenoma; TVA: Tubulovillous adenoma.