Impact of COVID-19 pandemic on clinicopathological features of transplant recipients with hepatocellular carcinoma: A case-control study

Table 2 Comparison of pre-pandemic and pandemic groups in terms of continuous variables

Variables	Pre-pandemic		Pandemic		P value
	Median (IQR)	95%CI	Median (IQR)	95%CI
Age	56 (17)	52-59	56 (14)	53-59	0.685
BMI	26 (5)	24-27	27 (5)	25-28	0.352
Graft weight	810 (220)	760-825	827 (272)	735-920	0.925
MELD score	15 (10)	12-17	16 (8)	13-18	0.413
AFP level	9 (36)	5-13	11 (82)	6-25	0.643
Tumor number	1 (3)	1-2	2 (2)	1-3	0.256
TTD	3.3 (3.8)	2.5-4.5	3.7 (6.3)	2.0-6.0	0.712
Liver index score	7 (2)	7-7	7 (2)	7-8	0.417
Agg index	4.0 (2.0)	4.0-5.0	5.0 (2.5)	4.0-6.0	0.183
WBC	6.0 (2.8)	5.0-7.0	4.9 (3.2)	4.0-6.0	0.298
Hb	13.0 (3.7)	12.0-14.0	11.9 (3.5)	11.0-13.0	0.079
Platelets	95 (90)	77-113	83 (102)	58-128	0.363
Neutrophil	3.5 (2.7)	2.9-4.1	2.8 (2.2)	2.5-3.7	0.394
Lymphocyte	1.1 (0.9)	0.9-1.6	1.1 (0.9)	0.9-1.3	0.498
NLR	2.7 (2.9)	2.1-3.4	2.6 (1.9)	2.1-3.1	0.819
PLR	76 (50)	64-91	76 (61)	59-93	0.634
INR	1.26 (0.40)	1.22-1.37	1.33 (0.43)	1.28-1.46	0.112
Creatinine	0.8 (0.3)	0.7-0.9	0.8 (0.2)	0.7-0.9	0.955
Albumin	2.9 (1.2)	2.6-3.1	2.9 (1.1)	2.6-3.1	0.888
Total bilirubin	1.7 (2.3)	1.2-2.1	2.3 (4.0)	1.4-2.8	0.138
Direct bilirubin	0.8 (1.4)	0.6-1.0	1.1 (1.5)	0.7-1.3	0.306
AST	57 (47)	46-63	57 (67)	46-86	0.157
ALT	41 (38)	33-50	40 (32)	30-52	0.944
ALP	107 (74)	93-122	131 (123)	109-158	0.029
GGT	78 (83)	61-107	61 (78)	44-105	0.213
LDH	224 (91)	202-255	247 (99)	210-273	0.325
CRP	0.7 (1.4)	0.4-1.2	0.9 (1.8)	0.5-1.9	0.533

95% confidence interval (CI) for median values. BMI: Body mass index; AFP: Alpha fetoprotein; WBC: White blood cell; NLR: Neutrophil to lymphocyte ratio; PLR: Platelet to lymphocyte ratio; INR: International normalized ratio; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; GGT: Glutamyl transpeptidase; LDH: Lactate dehydrogenase; CRP: C-reactive protein; TTD: Total diameter of the tumors; Hb: Hemoglobin; IQR: Interquartile range.