Reduced serum high-density lipoprotein cholesterol levels and aberrantly expressed cholesterol metabolism genes in colorectal cancer

Figure 4 Protein–protein interaction network of differentially expressed genes with prognostic value. Interacting nodes are displayed in colored circles using Search Tool for the Retrieval of Interacting Genes v10.0. A: Low-density lipoprotein receptor only involved in cholesterol metabolism pathway; B: FDXR was also involved in xenobiotic metabolic processes, cellular responses to xenobiotic stimuli and oxidation–reduction processes; C: ABCA1 was shown to be involved in the steroid hormone-mediated signaling pathway; D: OSBPL1A was involved in antigen processing and presentation of exogenous peptide antigens via MHC class II, microtubule-based movement and vesicle-mediated transport.