Clinical and prognostic significance of expression of phosphoglycerate mutase family member 5 and Parkin in advanced colorectal cancer

Table 2 Univariate analysis of overall survival and progression-free survival for colorectal cancer by Cox regression

Variable	OS			PFS
	HR	95%CI	P value	HR	95%CI	P value
Age (yr) (≥ 61/< 61)	0.706	0.393-1.266	0.242	0.877	0.526-1.464	0.616
Gender (male/female)	0.932	0.520-1.669	0.812	0.823	0.491-1.380	0.460
Tumor site (colon/rectum)	0.604	0.325-1.122	0.110	0.784	0.441-1.396	0.408
Size of the tumor, cm (> 4/≤ 4)	1.324	0.731-2.397	0.354	1.468	0.867-2.484	0.153
Histological type (mucinous/non-mucinous)	0.801	0.358-1.790	0.588	1.144	0.593-2.207	0.688
Degree of differentiation (poor/mucinous, well/moderate)	1.789	1.000-3.199	0.050	1.961	1.168-3.292	0.011
Angiolymphatic and/or perineural invasion (absent/present)	0.603	0.187-1.947	0.398	0.700	0.219-2.238	0.547
Tumor stage (III-IV/I-II)	4.117	2.122-7.985	< 0.001	3.390	1.945-5.908	< 0.001
Tumor invasion depth (T4/T2-T3)	2.085	1.157-3.758	0.014	1.987	1.185-3.331	0.009
Lymph node status (N1-N2/N0)	3.540	1.879-6.668	< 0.001	3.141	1.823-5.411	< 0.001
Distant metastasis (present/absent)	3.113	1.539-6.298	0.002	2.830	1.496-5.351	0.001
PGAM5 (low/high)	0.490	0.151-1.586	0.234	0.640	0.200-2.052	0.453
Parkin (low/high)	0.544	0.302-0.979	0.042	0.568	0.336-0.959	0.034
CEA (low/high)	0.752	0.413-1.368	0.351	0.791	0.469-1.336	0.382
CA19-9 (low/high)	1.369	0.739-2.536	0.318	1.196	0.702-2.038	0.510
P53 (high/low)	1.768	0.942-3.319	0.076	1.988	1.129-3.499	0.017
CDX2 (high/low)	1.314	0.588-2.939	0.506	1.285	0.632-2.615	0.488

OS: Overall survival; PFS: Progression-free survival; HR: Hazard ratio; CI: Confidence interval; PGAM5: Phosphoglycerate mutase family member 5; CEA: Carcinoembryonic antigen.