Effect of Xuebijing injection on myocardium during cardiopulmonary bypass: A prospective, randomized, double blind trial

doi:10.12998/wjcc.v10.i13.4110

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

World J Clin Cases. May 6, 2022; 10(13): 4110-4118
Published online May 6, 2022. doi: 10.12998/wjcc.v10.i13.4110

Table 3 Comparison of dynamic changes in respiratory function and inflammation- and oxidative stress-related markers during the perioperative periods between the Xuebijing injection and control groups

Group		Baseline	0 h	12 h	24 h	48 h
PaO₂/FiO₂	Saline	398.40 ± 22.66	361.92 ± 48.62	258.93 ± 39.03	320.64 ± 46.43	341.44 ± 35.28
PaO₂/FiO₂	XBJ	387.12 ± 35.77	358.48 ± 39.21	289.40 ± 44.07^a	353.34 ± 31.54^a	379.08 ± 22.54^a
CK-MB	Saline	0.26 ± 0.07	0.71 ± 0.12	2.74 ± 0.48	4.25 ± 0.83	1.95 ± 0.62
CK-MB	XBJ	0.26 ± 0.08	0.58 ± 0.12	2.27 ± 0.33^a	3.02 ± 0.44^a	1.09 ± 0.37^a
TnI	Saline	0.02 ± 0.01	1.45 ± 0.28	8.01 ± 1.13	13.03 ± 2.56	4.03 ± 0.92
TnI	XBJ	0.02 ± 0.01	1.38 ± 0.93	4.77 ± 0.76^a	8.29 ± 1.73^a	3.16 ± 0.43^a
TNF-α	Saline	13.51 ± 4.19	71.18 ± 29.21	147.36 ± 43.84	226.31 ± 60.22	122.48 ± 55.18
TNF-α	XBJ	15.61 ± 4.51	70.69 ± 27.24	125.64 ± 34.44^a	173.61 ± 40.03^a	99.96 ± 33.37^a
IL-1β	Saline	16.98 ± 4.14	32.95 ± 9.05	92.31 ± 18.45	78.43 ± 17.54	62.71 ± 15.40
IL-1β	XBJ	13.13 ± 4.22	28.23 ± 6.24	77.25 ± 9.16^a	66.15 ± 12.18^a	43.60 ± 13.33^a
IL-8	Saline	831.36 ± 136.86	1002.73 ± 180.26	1530.90 ± 235.96	1400.83 ± 268.85	1134.86 ± 211.41
IL-8	XBJ	767.30 ± 155.86	960.43 ± 187.49	1369.93 ± 244.21^a	1251.76 ± 240.81^a	984.86 ± 184.43^a
IL-10	Saline	90.60 ± 15.82	121.96 ± 18.15	167.41 ± 18.54	152.53 ± 33.94	121.26 ± 20.73
IL-10	XBJ	87.27 ± 20.83	123.30 ± 18.31	176.72 ± 27.91	166.97 ± 21.94^a	131.87 ± 19.52^a
MDA	Saline	0.11 ± 0.08	0.49 ± 0.19	0.14 ± 0.09	0.11 ± 0.08	0.11 ± 0.10
MDA	XBJ	0.09 ± 0.04	0.31 ± 0.12^a	0.13 ± 0.11	0.10 ± 0.06	0.10 ± 0.04
8-Isoprostane	Saline	1.84 ± 0.46	8.31 ± 0.76	6.29 ± 0.75	3.25 ± 0.52	1.83 ± 0.36
8-Isoprostane	XBJ	2.00 ± 0.55	6.63 ± 0.88^a	6.29 ± 0.75	3.24 ± 0.51	1.84 ± 0.53

^aP < 0.05. For continuous variables that were measured at multiple time points, repeated-measures analysis of variance was applied with Bonferroni’s correction as post-hoc analysis. PaO₂: Arterial oxygen tension; FiO₂: Fraction of inspired oxygen; CK-MB: Creatine kinase isoenzyme MB; TnI: Troponin I; TNF-α: Tumor necrosis factor-α; IL: interleukin; MDA: Malondialdehyde.

Citation: Jin ZH, Zhao XQ, Sun HB, Zhu JL, Gao W. Effect of Xuebijing injection on myocardium during cardiopulmonary bypass: A prospective, randomized, double blind trial. World J Clin Cases 2022; 10(13): 4110-4118
URL: https://www.wjgnet.com/2307-8960/full/v10/i13/4110.htm
DOI: https://dx.doi.org/10.12998/wjcc.v10.i13.4110