Correlation between thrombopoietin and inflammatory factors, platelet indices, and thrombosis in patients with sepsis: A retrospective study

Table 2 Univariable/multivariable analyses of sepsis

	Univariable			Multivariable
	OR	95%CI	P	OR	95%CI	P value
Age, yr	1.025	1.005-1.045	0.013	1.022	0.967-1.081	0.436
Gender
Male	Reference
Female	0.667	0.379-1.171	0.158
WBC	1.230	1.140-1.328	< 0.001	1.317	1.007-1.722	0.044
N#	1.315	1.202-1.439	< 0.001
RBC	0.404	0.272-0.600	< 0.001	1.398	0.376-5.197	0.617
Hb	0.972	0.960-0.985	< 0.001
TPO	1.016	1.010-1.022	< 0.001	1.021	1.005-1.037	0.009
IL-21	1.020	1.015-1.026	< 0.001	1.016	1.003-1.029	0.019
IL-6	1.066	1.039-1.093	< 0.001
hs-CRP	1.054	1.036-1.073	< 0.001
PLT	0.993	0.990-0.997	< 0.001	0.996	0.984-1.008	0.523
PDW	1.116	0.995-1.251	0.06
MPV	1.439	1.082-1.915	0.012	1.876	0.784-4.49	0.158
TBIL	1.084	1.04-1.13	< 0.001	1.023	0.925-1.131	0.658
Cre	1.005	1.001-1.008	0.004	0.993	0.981-1.005	0.26
TnI
≥ 0.01	66.731	19.556-227.712	< 0.001	55.199	5.686-535.903	0.001
< 0.01	Reference
DD	1.608	1.326-1.951	< 0.001	1.089	0.941-1.259	0.253
PT	2.677	2.004-3.576	< 0.001	2.235	1.097-4.554	0.027
APTT	1.310	1.190-1.443	< 0.001	1.057	0.809-1.381	0.684
TT	0.943	0.822-1.082	0.404
FIB	2.594	1.917-3.509	< 0.001	0.85	0.407-1.774	0.665

Variables with P < 0.05 in univariate analysis were entered in multivariate analysis, while variables with strong collinearity or correlation were excluded: IL-6, hs-CRP, PDW, N#, and Hb. OR: Odds ratio; CI: Confidence interval; WBC: White blood cell count; N#: Neutrophils; RBC: Red blood cell count; Hb: Hemoglobin concentration; TPO: Thrombopoietin; IL: Interleukin; hs-CRP: High-sensitivity C-reactive protein; PLT: Platelet count; PDW: Platelet distribution width; MPV: Mean platelet volume; TBIL: Total bilirubin; Cre: Creatinine; TnI: Troponin I; MAP: Mean arterial pressure; DD: D-dimer; PT: Prothrombin time; APTT: Activated partial thromboplastin time; TT: Thrombin time; INR: International normalized ratio; FIB: Fibrinogen.