Retrospective Study
Copyright ©The Author(s) 2022.
World J Clin Cases. May 6, 2022; 10(13): 4072-4083
Published online May 6, 2022. doi: 10.12998/wjcc.v10.i13.4072
Table 1 Characteristics of the patients
Clinical information
Total (n = 200)
Control group (n = 110)
Sepsis group (n = 90)
P value
Age, yr66 (54, 75)64 (51, 71)71 (57, 80)0.002
Sex, male, n (%)109.0 (54.5)55.0 (50.0)54.0 (60.0)0.158
Hypertension, n (%)40.0 (36.4)
Infection site
Lungs, n (%)22.0 (24.4)
Abdomen, n (%)54 (60)
Skin and soft tissue infections, n (%)4.0 (4.4)
Central nervous system infection, n (%)1.0 (1.1)
Others, n (%)9 (10)
SOFA, n (%)5 (3, 7)
WBC, × 109/L9.20 (7.15, 13.58)8.03 (6.55, 10.29)13.12 (8.80, 18.39)< 0.001
N#, × 109/L7.02 (4.88, 11.47)5.75 (4.11, 7.28)10.69 (7.24, 16.58)< 0.001
RBC, × 1012/L4.30 (3.67, 4.77)4.44 (4.13, 4.88)3.83 (3.24, 4.53)< 0.001
Hb, g/L129.5 (107.0, 145.0)134.5 (126.0, 148.0)110.5 (98.0, 136.0)< 0.001
PLT, × 109/L221.0 (159.5, 276.0)241 (198, 283)174.5 (118, 251)< 0.001
PDW, fL11.9 (10.6, 13.5)11.80 (10.55, 12.95)11.90 (10.60, 14.15)0.343
P-LCR0.28 (0.23, 0.34)0.280 (0.230, 0.325)0.30 (0.23, 0.37)0.059
MPV, fL10.4 (9.8, 11.2)10.3 (9.8, 11.0)10.5 (9.9, 11.6)0.035
TPO, pg/mL37.91 (6.10, 107.91)12.45 (0.64, 46.09)86.45 (30.55, 193.1)< 0.001
IL-21, pg/mL506 (418, 566)436 (366, 493)565 (524, 610)< 0.001
IL-6, pg/mL16.7 (4.6, 219.0)5.0 (2.0, 12.0)310.4 (41.9, 1582.4)< 0.001
hs-CRP, mg/L10.8 (1.6, 114.4)2.1 (0.8, 6.1)130.7 (58.4, 196.5)< 0.001
PCT, ng/mL10.26 (0.97, 31.70)
TBIL, µmol/L11.05 (8.5, 16.9)10.10 (7.75, 14.00)14.25 (9.60, 23.00)< 0.001
Cre, µmol/L78 (60, 133)69 (55, 87)120.5 (73.0, 187.0)< 0.001
TnI, ng/mL< 0.001
≥ 0.01, n (%)61.0 (30.7)3.0 (2.7)58.0 (65.2)
< 0.01, n (%)138.0 (69.3)107.0 (97.3)31.0 (34.8)
Oxygenation index< 0.001
≥ 400, n (%)124.0 (64.9)110 (100)14.0 (17.3)
< 400, n (%)67.0 (35.1)0 (0)67.0 (82.7)
MAP, mmHg< 0.001
≥ 70, n (%)161.0 (80.9)110.0 (100.0)51.0 (57.3)
< 70, n (%)38.0 (19.1)0 (0)38.0 (42.7)
DD, µg/mL0.960 (0.340, 2.795)0.38 (0.22, 0.82)3.120 (1.395, 6.440)< 0.001
PT, s12.50 (11.60, 14.05)11.8 (11.2, 12.5)14.0 (13.1, 15.4)< 0.001
APTT, s27.15 (24.95, 30.60)26.4 (24.7, 27.8)30.1 (26.5, 34.6)< 0.001
TT, s16.2 (15.3, 17.2)16.60 (15.75, 17.40)15.7 (14.8, 16.7)< 0.001
INR1.090 (1.010, 1.225)1.03 (0.97, 1.09)1.22 (1.14, 1.34)< 0.001
FIB, g/L3.450 (2.750, 4.655)2.91 (2.58, 3.48)4.58 (3.65, 5.95)< 0.001
All data are shown as the median (P25, P75) or n (%). SOFA: Sequential organ failure assessment; N#: Neutrophile; WBC: White blood cell count; RBC: Red blood cell count; Hb: Hemoglobin concentration; PLT: Platelet count; PDW: Platelet distribution width; P-LCR: Platelet large-cell ratio; MPV: Mean platelet volume; TPO: Thrombopoietin; IL: Interleukin; hs-CRP: High-sensitivity C-reactive protein; PCT: Procalcitonin; TBIL: Total bilirubin; Cre: Creatinine; TnI: Troponin I; MAP: Mean arterial pressure; DD: D-dimer; PT: Prothrombin time; APTT: Activated partial thromboplastin time; TT: Thrombin time; INR: International normalized ratio; FIB: Fibrinogen.