Solute carrier family 2 members 1 and 2 as prognostic biomarkers in hepatocellular carcinoma associated with immune infiltration

Table 4 Correlation analysis between solute carrier family 2 member 1 and solute carrier family 2 and genes markers of immune cells in gene expression profiling interactive analysis

Description	Gene markers	Solute carrier family 2 member 1		Solute carrier family 2 member 2
		cor	P value	cor	P value
CD8+ T cell
	CD8A	0.24	3.10E-06	-0.084	1.10E-01
	CD8B	0.26	3.20E-07	-0.13	1.40E-02
T cell (general)
	CD3D	0.18	5.10E-04	-0.23	1.10E-05
	CD3E	0.15	4.00E-03	-0.11	3.90E-02
	CD2	0.17	1.50E-03	-0.12	2.60E-02
B cell
	CD19	0.22	1.60E-05	-0.073	1.60E-01
	CD79A	0.036	4.90E-01	-0.59	2.60E-01
Monocyte
	CD86	0.39	1.50E-14	-0.16	1.70E-03
	CD115 (CSF1R)	0.36	1.40E-12	-0.14	5.40E-03
Tumor-associated macrophage
	CCL2	0.16	2.30E-03	-0.13	1.50E-02
	CD68	0.27	9.20E-08	-0.14	6.50E-03
	IL10	0.32	2.50E-10	-0.095	6.70E-02
M1 macrophage
	INOS (NOS2)	-0.031	5.50E-01	0.2	1.20E-04
	IRF5	0.14	7.40E-03	0.044	4.00E-01
	COX2 (PTGS2)	0.16	1.50E-03	-0.028	5.90E-01
M2 macrophage
	CD163	0.31	7.00E-10	-0.13	1.40E-02
	VSIG4	0.36	1.10E-12	-0.12	1.80E-02
	MS4A4A	0.29	1.50E-08	-0.11	2.80E-02
	CD66b (CEACAM8)	0.074	1.60E-01	-0.018	7.30E-01
Neutrophil
	CD11b (ITGAM)	0.28	5.80E-08	-0.074	1.60E-01
	CCR7	0.039	4.60E-01	-0.028	5.90E-01
Natural killer cell
	KIR2DL1	0.087	9.40E-02	-0.059	2.60E-01
	KIR2DL3	0.13	1.40E-02	-0.05	3.40E-01
	KIR2DL4	0.18	7.10E-04	-0.12	2.00E-02
	KIR3DL1	0.086	9.70E-02	-0.058	2.70E-01
	KIR3DL2	0.069	1.90E-01	-0.0081	8.80E-01
	KIR3DL3	0.08	1.30E-01	-0.068	1.90E-01
	KIR2DS4	0.044	4.00E-01	0.02	7.10E-01
Dendritic cell
	HLA-DPB1	0.25	1.40E-06	-0.16	2.20E-03
	HLA-DQB1	0.14	8.10E-03	-0.19	2.60E-04
	HLA-DRA	0.26	6.00E-07	-0.15	5.00E-03
	HLA-DPA1	0.2	8.00E-05	-0.12	2.30E-02
	BDCA-1 (CD1C)	0.12	2.40E-02	-0.044	4.00E-01
	BDCA-4 (NRP1)	0.23	6.80E-06	-0.037	4.80E-01
	CD11c (ITGAX)	0.24	2.00E-06	-0.13	1.40E-02
Th1
	T-bet (TBX21)	0.088	9.00E-02	-0.058	2.70E-01
	STAT4	0.0027	9.60E-01	-0.041	4.40E-01
	STAT1	0.13	1.10E-02	0.017	7.50E-01
	IFN-γ (IFNG)	0.19	3.30E-04	-0.1	4.70E-02
	TNF-α (TNF)	0.12	2.00E-02	-0.1	5.40E-02
Th2
	GATA3	0.31	2.10E-09	-0.13	1.20E-02
	STAT6	0.15	4.80E-03	0.19	2.40E-04
	STAT5A	0.2	8.20E-05	-0.07	1.80E-01
	IL13	-0.025	6.30E-01	-0.01	8.40E-01
Tfh
	BCL6	0.1	4.70E-02	0.24	2.70E-06
	IL21	0.072	1.70E-01	-0.044	3.90E-01
Th17
	IL17A	-0.022	6.70E-01	0.071	1.80E-01
T cell regulatory
	FOXP3	-0.036	4.90E-01	0.17	1.40E-03
	CCR8	0.16	1.90E-03	-0.082	1.20E-01
	STAT5B	0.073	1.60E-01	0.43	0.00E+00
	TGFβ (TGFB1)	0.24	2.10E-06	-0.25	1.40E-06
T cell exhaustion
	PD-1 (PDCD1)	0.08	1.20E-01	-0.12	2.00E-02
	CTLA4	0.17	1.10E-03	-0.18	7.20E-04
	LAG3	0.23	7.60E-06	-0.19	3.30E-04
	TIM-3 (HAVCR2)	0.22	1.30E-05	-0.17	1.30E-03
	GZMB	0.17	8.10E-04	-0.16	2.20E-03

cor: Correlation coefficient; L10: Interleukin 10; INOS: Nitric oxide synthase 2; IRF5: Interferon regulatory factor 5; COX2: Cytochrome c oxidase subunit II; VSIG4: V-set and immunoglobulin domain containing 4; MS4A4A: Membrane spanning 4-domains A4A; CCR7: C-C motif chemokine receptor 7; KIR2DL1: Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1; KIR2DL3: Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3; KIR2DL4: Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4; KIR3DL1: Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1; KIR3DL2: Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2; KIR3DL3: Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3; KIR2DS4: Killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4; HLA-DPB1: Major histocompatibility complex, class II, DP beta 1; HLA-DQB1: Major histocompatibility complex, class II, DQ beta 1; HLA-DRA: Major histocompatibility complex, class II, DR alpha; HLA-DPA1: Major histocompatibility complex, class II, DP alpha 1; BDCA-4: Neuropilin 1; T-bet: T-box transcription factor 21; STAT4: Signal transducer and activator of transcription 4; STAT1: Signal transducer and activator of transcription 1; IFN-γ: Interferon gamma; TNF-α: Tumor necrosis factor; GATA3: GATA Binding protein 3; STAT6: Signal transducer and activator of transcription 6; STAT5A: Signal transducer and activator of transcription 5A; IL13: Interleukin 13; BCL6: BCL6 transcription repressor; IL21: Interleukin 21; IL17A: Interleukin 17A; FOXP3: Forkhead box P3; CCR8: C-C motif chemokine receptor 8; STAT5B: Signal transducer and activator of transcription 5B; TGFβ: Transforming growth factor-beta; PD-1: Programmed cell death 1; CTLA4: Cytotoxic T-lymphocyte associated protein 4; LAG3: Lymphocyte activating 3; TIM-3: Hepatitis A virus cellular receptor 2; GZMB: Granzyme B; Th: T helper; Tfh: Follicular helper T.