Circulating tumor DNA genomic profiling reveals the complicated olaparib-resistance mechanism in prostate cancer salvage therapy: A case report

Figure 3 Diagram of the predicted homologous recombination repair gene PALB2 protein sequence changes caused by the germline mutation (c. 751C>T) and the two somatic reverse mutations (c.751_752delCAinsTT and c.751_753delCAGinsTAC) on the same loci detected in ctDNA from the patient presenting with resistance of olaparib PAPR inhibitor in combination with abiraterone. HRR: Homologous recombination repair; PALB2: Partner and localizer of BRCA2; WT: Wild-type. Stop codon; nonsense mutation.