Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer

Figure 4 Overexpression of circ_0000375 and circ_0011536 suppresses proliferation, migration and invasion in colorectal cancer. A: The relative expression levels of circ_0000375 and circ_0011536 in SW480 cells transfected with overexpression plasmids; B: The relative expression levels of circ_0000375 and circ_0011536 in HCT116 cells transfected with overexpression plasmids; C: Cell counting kit-8 (CCK-8) assays were performed to determine the ability of proliferation in SW480 cells transfected with oe-circ_0000375 or oe-circ_0011536; D: CCK-8 assays were performed to determine the ability of proliferation in HCT116 cells transfected with oe-circ_0000375 or oe-circ_0011536; E: Wound healing assays were conducted to assess the cell migrative capability of SW480; F: Wound healing assays were conducted to assess the cell migrative capability of HCT116 cells; G: Transwell invasion assays were utilized to reveal the invasive ability of SW480; H: Transwell invasion assays were utilized to reveal the invasive ability of HCT116 cells; I: Results of wound healing assays of SW480 and HCT116 cell lines; J: Results of Transwell invasion assays of SW480 and HCT116 cell lines. ^aP < 0.001; ^bP < 0.01; ^cP < 0.05.