Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer

Figure 3 Circ_0000375 and circ_0011536 were downregulated in colorectal cancer tissue and serum samples. A: The expression levels of circ_0000375 in healthy control (HC) and colorectal cancer (CRC) tissue samples; B: The expression levels of circ_0011536 in HC and CRC tissue samples; C: Receiver operating characteristic curves for circ_0000375, circ_0011536 and combined circular ribonucleic acids in CRC tissues with the area under the curve calculated; D: The expression levels of circ_0000375 in serum samples of HC, preoperative CRC and CRC after surgery; E: The expression levels of circ_0011536 in serum samples of HC, preoperative CRC and CRC after surgery; F: Receiver operating characteristic curves for Circular ribonucleic acids in CRC serum samples. ^aP < 0.001; ^bP < 0.01; ^cP < 0.05. CRC: Colorectal cancer; HC: Healthy control; AUC: Area under the curve; ROC: Receiver operating characteristic.