Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer

Figure 1 Expression profiles of circular ribonucleic acids in colorectal cancer tissues from GSE126095 datasets and in cell lines. A: Volcano plot of circular ribonucleic acids expression levels; B: The expression of circ_0000375 in colorectal cancer (CRC) tissues and negative control tissues; C: The expression of circ_0011536 in CRC tissues and negative control tissues; D: Receiver operating characteristic curves to evaluate the diagnostic value of circ_0000375 and circ_0011536 by assessing the area under the curve; E: The relative expression levels of circ_0000375 in a normal colon cell line (FHC) and CRC cell lines (HCT116, RKO and SW480); F: The relative expression levels of circ_0011536 in a normal colon cell line (FHC) and CRC cell lines (HCT116, RKO and SW480). ^aP < 0.001; ^bP < 0.01; ^cP < 0.05. NC: Negative control; AUC: Area under the curve; CRC: Colorectal cancer.