Encouraging specific biomarkers-based therapeutic strategies for hepatocellular carcinoma

Table 1 Amino acid peptide sequences and immunogenicity of alpha-fetoprotein epitopes

No.	Starting	Numbers	Fragment	Immunogenicity
1	7	9	IFLIFLLNF	Sub-immunodominant Ag
2	137	9	PLFQVPEPV	Immunodominant Ag
3	150	9	AYEEDRETF	Sub-immunodominant Ag
4	158	9	FMNKFIYEI	Immunodominant Ag
5	218	9	LLNQHACAV	Sub-immunodominant Ag
6	235	9	FQAITVTKL	Sub-immunodominant Ag
7	249	10	KVNFTEIQKL	Immunodominant Ag
8	307	9	TTLERGQCII	Sub-immunodominant Ag
9	321	9	KPEGLSPNL	Immunodominant Ag
10	325	10	GLSPNLNRFL	Immunodominant Ag
11	357	9	EYSRRHPQL	Immunodominant Ag
12	364	10	QLAVSVILRV	Immunodominant Ag
13	403	9	KYIQESQAL	Immunodominant Ag
14	414	9	RSCGLFQKL	Immunodominant Ag
15	424	9	EYYLQNAFL	Immunodominant Ag
16	434	9	AYTKKAPQL	Immunodominant Ag
17	485	10	CIRHEMTPV	Sub-immunodominant Ag
18	492	9	PVNPGVGQC	Sub-immunodominant Ag
19	503	9	SYANRRPCF	Sub-immunodominant Ag
20	507	10	NRRPCFSSLV	Sub-immunodominant Ag
21	542	9	GVALQTMKQ	Immunodominant Ag
22	547	10	TMKQEFLINL	Sub-immunodominant Ag
23	555	9	NLVKQKPQI	Sub-immunodominant Ag
24	591	9	CFAEEGQKL	Sub-immunodominant Ag

Ag: Antigen; Fragment: Fragment of alpha-fetoprotein (AFP) peptide chain; Numbers: Amino acid numbers of AFP peptide chain; Starting: Starting point of AFP peptide chain.