Endoscopic submucosal dissection combined with adjuvant chemotherapy for early-stage neuroendocrine carcinoma of the esophagus: A case report

Figure 3 Histologic characteristics of the neuroendocrine carcinoma. A: The gross specimen was a nodular tumor; B: Depth of invasion was classified as SM2 (submucosal invasion ≥ 200 µm); C: The poorly differentiated neoplasm comprising large cells with marked nuclear atypia, multifocal necrosis, and 20 mitotic figures per ten high-power fields; D: Ki-67 labeling index was 80%; E: Syn+; F: CD56+; G: CD31-; H: CD240-.