Targeting metabolism: A potential strategy for hematological cancer therapy

Figure 1 Summary of various signaling pathways of hematological cancers that induce cancer development and therapy resistance. A: Hypoxia signaling; B: Ras/Raf/MAPK signaling; C: RTK signaling; D: PI3K-AKT/Ras-ERK/mTOR signaling; E: NF-κB signaling. HIF: Hypoxia-inducible factor; IGF: Insulin-like growth factor; HRG: Heregulin; CBP: Cyclic AMP response-element-binding protein; TGF: Transforming growth factor; EGFR: Epidermal growth factor receptor; GSK: Glycogen synthase kinase; PDK: Phosphoinositide-dependent kinases; PKC: Protein kinase C; mTORC: Mammalian target of rapamycin complex; mTOR: Mammalian target of rapamycin; RTK: Receptor tyrosine kinase; NF-κB: Nuclear factor-kappaB.