Effects of physical exercise on the quality-of-life of patients with haematological malignancies and thrombocytopenia: A systematic review and meta-analysis

Table 2 Characteristics of randomized controlled trial

Ref.	Year	Country	Assigned group	Randomly assigned participants (N)	Types of any participants	Intervention time	Outcomes
Jarden et al[28]	2009	Copenhagen	Control: Eoutine care	16	Adult patients scheduled for a myeloablative allo-HSCT platelets > 20 × 109/L	6 mo	Quality of life (EORTC QLQ-C30): (1) At 3 mo, case (65.1 ± 15.9) vs control (51.9 ± 20.2); P = 0.841; (2) At 6 mo, case (72.8 ± 20.0) vs control (58.3 ± 21.5); P = 0.603
			Experimental: Stretching exercises; resistance training; relaxation and psychoeducation	13
Baumann et al[29]	2010	Germany	Control: Routine care	25	Adult patients with the indication of an HSCT platelets > 30 × 109/L	The entire hospitalization phase	Quality of life (EORTC QLQ-C30): Case (61.2 ± 22.8) vs control (61.7 ± 22.1); P = 0.926
			Experimental: Aerobic endurance, training and ADL-training	24
Baumann et al[30]	2011	Germany	Control: Routine care	16	Adult patients undergoing an allo-HSCT platelets > 10 × 109/L	The whole inpatient time	Quality of life (EORTC QLQ-C30): Case (68.6± 11.2) vs control (56.3 ± 17.6)
			Experimental: Aerobic endurance, training and ADL-training, interval training, resistance training	17
Oechsle et al[31]	2014	Germany	Control: Routine care	24	Adult patients with acute myeloid leukemia platelets > 20 × 109/L	During the hospitalization 21 d (range: 16-33 d)	Quality of life (EORTC QLQ-C30): Case 50 vs control 50. P = 0.66
			Experimental: Endurance training, resistance exercises	24
Bryant et al[32]	2018	United States	Control: Routine care	9	Adult newly diagnosed with acute leukemia platelets > 10 × 109/L	During the hospitalization	PROMIS short form measures, self-reported measures of HRQOL
			Experimental:Aerobic training, resistance training	8
Wehrle et al[33]	2019	Germany	Control: Routine care	8	Adult patients diagnosed with AL platelets > 10 × 109/L	During induction chemotherapy	Quality of life (EORTC QLQ-C30): Case 1 62.5 (45.8-70.8) case 2 50.0 (33.3-58.3); vs control 66.7 (45.8-66.7)
			Experimental 1: Aerobic training	8
			Experimental 2: Resistance training	6
Pahl et al[34]	2020	Germany	Control: Routine care	23	Adult patients during allo-HSCT, platelets > 20 × 109/L	During the hospitalization	After hospitalization, CG patients reported reduced QoL (P = 0.015), IG’s QoL remained unchanged

QoL: Quality of life; PROMIS: Patient-Reported Outcomes Measurement Information System; allo-HSCT: Allogeneic hematopoietic stem cell transplant; ADL: Activities of daily living; AL: Acute leukemia; WBV: Whole body vibration; CG: Control group; IG: Intervention group; EORTC QLQ-C30: European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30; HRQOL: Health-related quality of life.