Retrospective Study
Copyright ©The Author(s) 2022.
World J Clin Cases. Apr 6, 2022; 10(10): 3078-3087
Published online Apr 6, 2022. doi: 10.12998/wjcc.v10.i10.3078
Table 2 Univariate and multivariate analyses for prognostic factors for overall survival in patients with extrahepatic cholangiocarcinoma
Univariate analysis for overall survival

Hazard ratio (95%CI)
P value
Age (> 70 yr old) 1.98 (1.21–3.23)< 0.01
Gender (female)1.18 (0.37–3.72)0.32
Location of tumor0.02
distal CBD1
prox. CBD0.32 (0.10–1.02)0.06
CHD or Klatskin tumor3.73 (0.69–20.2)0.13
Op method0.35
BDR1
PPPD or Whipple operation1.09 (0.97- 1.23)0.42
BDR + hepatectomy1.88 (0.28-12.63)0.51
BDR+ PPPD or Whipple + hepatectomy19.35 (2.78-134.64)< 0.01
Resection margin< 0.01
Negative1
LGD positive0.83 (0.42-1.63)0.58
HGD/CIS positive7.72 (1.04-57.52)0.001
T stage0.283
T11
T20.95 (0.15-5.94)0.105
T31.53 (0.82-3.14)0.283
N stage
N(-)1
N(+)1.31 (0.96-2.54)0.120
Perineural invasion1.28 (0.8-2.1)0.329
Lymphatic invasion1.13 (0.7-1.9)0.624
Differentiation 1.16 (0.5-2.6)0.814
Well 1
Moderate0.73 (0.20-2.63)0.625
Poor2.07 (0.50-8.56)0.317
CA 19-91.00 (0.99-1.00)0.592
Comorbidity1.38 (0.92-2.21)0.173
History of malignancy0.88 (0.4-1.8)0.707
Adjuvant therapy 0.31 (0.11-0.86)0.024
Multivariate analysis for overall survival
Age (≥ 70 yr old)1.9 (1.2-3.1)0.01
HGD/CIS positive margin2.47 (1.4-4.2)0.002