Dose-response relationship between risk factors and incidence of COVID-19 in 325 hospitalized patients: A multicenter retrospective cohort study

Table 6 Associations of risk factors with severe cases incident risk of coronavirus disease 2019

Variable	OR (95%CI)		P for overall association	P for nonlinear association
	Model 1	Model 2
Age (per year increase)	1.06 (1.04, 1.08)	1.04 (1.01, 1.07)	0.010	0.192
WBC (per 1 × 109/L increase)	1.27 (1.11, 1.46)	1.20 (1.01, 1.45)	0.003	0.046
FBG (per 1 mmol/L increase)	1.19 (1.07, 1.33)	1.15 (1.01, 1.32)	0.036	0.064
Total cholesterol (per 1 mmol/L increase)	1.43 (1.07, 1.91)	1.65 (1.09, 2.50)	0.028	0.260
LDH (per 10 U/L increase)	1.09 (1.05, 1.13)	1.06 (1.02, 1.10)	0.009	0.268
Procalcitonin (per 1 ng/mL increase of NLT)	2.26 (1.68, 3.05)	1.75 (1.16, 2.65)	0.007	0.099

Hazard ratios are reported per 1-SD increase in loge D-dimer (DD) and Procalcitonin levels; 1-SD higher loge DD and procalcitonin was approximately equivalent to 2-fold higher DD and Procalcitonin. Model 1: Adjusted age, sex. Model 2: Adjusted model 1 plus smoking status, history of hypertension, diabetes, cancers, cardiac disease, and chronic pulmonary disease, systolic blood pressure, fasting blood glucose, total cholesterol, triglyceride, white blood cell count, C-reactive protein, creatinine, DD, LDH, procalcitonin. LDH: Lactate dehydrogenase; NLT: Natural log-transformation. CI: Confidence interval.