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©The Author(s) 2022.
World J Clin Cases. Jan 7, 2022; 10(1): 242-248
Published online Jan 7, 2022. doi: 10.12998/wjcc.v10.i1.242
Published online Jan 7, 2022. doi: 10.12998/wjcc.v10.i1.242
Table 2 Genetic and clinical features of different types of hemophilia and their management
Hemophilia A | Hemophilia B | Hemophilia C | |
Genetics | X-linked | X-linked | Autosomal |
Pathophysiology | FVIII deficiency | FIX deficiency | FXI deficiency |
Clinical manifestations | Bleeding of variable severity correlated with factor levels | Bleeding of variable severity correlated with factor levels | Variable |
Routine management | Prophylactic factor replacement | Prophylactic factor replacement | None |
Perioperative management | Factor replacement, Cryoprecipitate. The goal is to keep the levels of FVIII > 50% for major surgery | Factor replacement, Prothrombin complex concentrate. The goal is to keep the levels of factor IX > 50% for major surgery | Controversial. May include: FFP, antifibrinolytics, TPE, factor replacement. Optimal FXI level unclear |
- Citation: Guo WJ, Chen WY, Yu XR, Shen L, Huang YG. Intraoperative thromboelastography-guided transfusion in a patient with factor XI deficiency: A case report. World J Clin Cases 2022; 10(1): 242-248
- URL: https://www.wjgnet.com/2307-8960/full/v10/i1/242.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v10.i1.242