Influence of overweight and obesity on the mortality of hospitalized patients with community-acquired pneumonia

doi:10.12998/wjcc.v10.i1.104

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World Journal of Clinical Cases

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World J Clin Cases. Jan 7, 2022; 10(1): 104-116
Published online Jan 7, 2022. doi: 10.12998/wjcc.v10.i1.104

Table 1 Clinical and laboratory characteristics of 2327 patients admitted to hospital with pneumonia in different body mass index groups

Characteristics	BMI categories (kg/m²)			P value
Characteristics	< 18.5 (n = 297)	18.5-23.9 (n = 1013)	≥ 24 (n = 1017)	P value
Age (yr), (median, IQR), n (%)	77 (63, 84)	68 (56, 79)^a	65 (53, 77)^c	< 0.001
< 65	80 (26.9)	416 (41.4)^a	476 (46.8)^b^,^c	< 0.001
≥ 65	217 (73.1)	597 (58.9)^a	541 (53.2)^b^,^c	< 0.001
Sex, n (%)				0.025
Male	156 (52.5)	617 (60.9)^a	581 (57.2)
Female	141 (47.5)	396 (39.1)^a	436 (42.8)
Diabetes history, n (%)				0.002
No	260 (87.4)	995 (81.3)	758 (74.3)^b^,^c
Yes	37 (12.6)	185 (18.7)	259 (25.7)^b^,^c
Consciousness, n (%)				< 0.001
Conscious	247 (83.2)	919 (90.7)^a	948 (93.3)^c
Confusion	50 (16.8)	94 (9.3)^a	69 (6.7)^c
RR (breaths/min), (median, IQR), n (%)	20 (20, 21)	20 (20, 20)^a	20 (20, 20)	0.036
< 30	282 (94.9)	975 (96.2)	974 (95.8)	0.597
≥ 30	15 (5.1)	38 (3.8)	43 (4.2)	0.597
SBP (mmHg), (median, IQR), n (%)	121.5 (110.0, 142.0)	127.0 (113.0, 140.0)^a	130.0 (120.0, 145.0)^b^,^c	< 0.001
≥ 90	280 (94.3)	990 (97.7)^a	1002 (98.5)^c	< 0.001
< 90	17 (5.7)	23 (2.3)^a	15 (1.5)^c	< 0.001
DBP (mmHg), (median, IQR), n (%)	73.0 (65.0, 81.0)	77.0 (70.0, 84.0)^a	80.0 (70.0, 88.0)^b^,^c	< 0.001
> 60	248 (83.5)	890 (87.9)	933 (91.7)^b^,^c	< 0.001
≤ 60	49 (16.5)	123 (12.1)	84 (8.3)^b^,^c	< 0.001
WBC (10⁹/L), (median, IQR), n (%)	8.56 (6.03, 12.85)	8.19 (5.84, 11.73)^a	7.99 (5.86, 11.31)^c	0.039
Normal	159 (53.5)	554 (54.7)	576 (56.7)	0.519
Abnormal	138 (46.5)	459 (45.3)	441 (43.3)	0.519
NEUT (10^9/L), (median, IQR), n (%)	6.75 (4.28, 10.64)	6.03 (3.78, 9.49)^a	5.68 (3.75, 8.79)^c	0.002
Normal	125 (42.1)	478 (47.2)^a	516 (50.7)^c	0.025
Abnormal	172 (57.9)	535 (52.8)^a	501 (49.3)^c	0.025
CRP (mg/L), (median, IQR), n (%)	48.26 (10.55, 105.05)	26.53 (5.96, 79.17)^a	21.24 (2.92, 72.30)^b^,^c	< 0.001
Normal	58 (19.5)	266 (26.3)	313 (30.7)^c	< 0.001
Abnormal	239 (80.5)	747 (73.7)	704 (69.3)^c	< 0.001
BUN (mmol/L), (median, IQR), n (%)	6.30 (4.30, 9.45)	5.60 (4.20, 8.10)^a	5.50 (4.10, 7.38)^c	0.001
Normal	177 (59.6)	656 (64.8)^a	721 (71.0)^b^,^c	< 0.001
Abnormal	120 (40.4)	357 (35.2)^a	296 (29.0)^b^,^c	< 0.001
ALB (g/L), (median, IQR), n (%)	33.0 (29.9, 37.2)	34.7 (31.0, 38.3)^a	36.9 (33.2, 40.1)^b^,^c	< 0.001
Normal	98 (33.0)	461 (45.5)^a	621 (61.1)^b^,^c	< 0.001
Abnormal	199 (67.0)	552 (54.5)^a	396 (38.9)^b^,^c	< 0.001
HOD (d), (median, IQR), n (%)	10 (7, 15)	10 (7, 14)	10 (7, 14)	0.599
Ventilator use	47 (16.0)	108 (10.7)^a	95 (9.4)^c	0.006
ICU admission	61 (20.5)	182 (18.0)	123 (12.1)^b^,^c	< 0.001
CURB-65 score, (median, IQR), n (%)	1 (1, 2)	1 (0, 2)^a	1 (0, 2)^b^,^c	< 0.001
Low risk	156 (52.5)	675 (66.6)^a	745 (73.2)^b^,^c	< 0.001
Moderate risk	86 (29.0)	236 (23.3)^a	205 (20.2)^b^,^c
High risk	205 (20.2)	102 (10.1)^a	67 (6.6)^b^,^c
Death, n (%)	27 (9.1)	51 (5.0)^a	28 (2.8)^b^,^c	< 0.001

^aP < 0.05, body mass index (BMI) 18.5-23.9 kg/m² group vs BMI <18.5 kg/m² group.

^bP < 0.05, BMI ≥ 24 kg/m² group vs BMI 18.5-23.9 kg/m² group.

^cP < 0.05, BMI < 18.5 kg/m² group vs BMI ≥ 24 kg/m² group.

Data are expressed as median with interquartile ranges or n with percentiles (%). When data were not normally distributed, they were Log-n transformed for analysis. The CURB-65 score is a tool for assessing the severity of patients with community-acquired pneumonia, including new onset confusion; urea > 7 mmol/L; respiratory rate ≥ 30 breaths/min, systolic blood pressure < 90 mmHg and/or diastolic blood pressure ≤ 60 mmHg; and age ≥ 65 years. BMI: Body mass index; IQR: Interquartile range; ALB: Albumin; BUN: Blood urea nitrogen; CRP: C-reactive protein; DBP: Diastolic blood pressure; HOD: Hospital day; ICU: Intensive care unit; NEUT: Neutrophil granulocyte; RR: Respiratory rate; SBP: Systolic blood pressure; WBC: White blood cell.

Citation: Wang N, Liu BW, Ma CM, Yan Y, Su QW, Yin FZ. Influence of overweight and obesity on the mortality of hospitalized patients with community-acquired pneumonia. World J Clin Cases 2022; 10(1): 104-116
URL: https://www.wjgnet.com/2307-8960/full/v10/i1/104.htm
DOI: https://dx.doi.org/10.12998/wjcc.v10.i1.104