Renal cell carcinoma: Evolving and emerging subtypes

Figure 9 Hybrid oncocytoma/chromophobe renal cell carcinoma (hematoxylin and eosin). A: Low power assessment of the tumors shows a well-circumscribed tumor with a solid growth pattern (× 40); B: The tumor cells have abundant eosinophilic cytoplasm and round, monotonous nuclei (× 200); C: Perinuclear halos are prominent throughout, with some areas showing mild nuclear irregularity (× 400). The overlapping features of oncocytoma (round nuclei with abundant eosinophilic cytoplasm) and chromophobe (perinuclear halos) are noted.