Renal cell carcinoma: Evolving and emerging subtypes

Figure 6 Acquired cystic disease-associated renal cell carcinoma. A, B: The tumor cells in acquired cystic disease-associated renal cell carcinoma typically have abundant eosinophilic cytoplasm and are seen lining the cystic spaces (A, × 400), and sometimes also show a solid growth pattern (B, × 200); The tumor characteristically arranges in a sieve-like cribriform pattern; C: The nuclear features are consistent with a Fuhrman nuclear grade 3, with prominent nucleoli (× 600); D, E: Calcium oxalate crystals are often associated with these tumors, and can be seen on hematoxylin and eosin staining (D, × 600) and with polarization (E, × 100).